Alexander Shulgin

Alexander Shulgin
Born June 17, 1925 (1925-06-17) (age 86)
Berkeley, California
Nationality American
Education Ph.D. from UC Berkeley in Biochemistry, post-doctoral work in the fields of psychiatry and pharmacology
Occupation Psychopharmacologist
Title "The Godfather of Psychedelics" [1]
Spouse Ann Shulgin
Website
CaringBridge website

Alexander "Sasha" Theodore Shulgin[2] (born June 17, 1925) is an American pharmacologist, chemist, artist, and drug developer.

Shulgin is credited with the popularization of MDMA, commonly known as ecstasy, in the late 1970s and early 1980s, especially for psychopharmaceutical use and the treatment of depression and post-traumatic stress disorder. In subsequent years, Shulgin discovered, synthesized, and bioassayed over 230 psychoactive compounds. In 1991 and 1997, he and his wife Ann Shulgin authored the books PiHKAL and TiHKAL on the topic of psychoactive drugs. Shulgin discovered many noteworthy phenethylamines including the 2C* family of which 2C-T-2, 2C-T-7, 2C-E, 2C-I, and 2C-B are most well known. Additionally, Shulgin performed seminal work into the descriptive synthesis of compounds based on the organic compound tryptamine.

Contents

Life and career

Shulgin was born in Berkeley, California to Russian parents, Theodore Stevens Shulgin (1893–1978)[3] and Henrietta D. Shulgin (1888–1960).[4] Both Theodore and Henrietta were public school teachers in Alameda County.[5]

Shulgin began studying organic chemistry as a Harvard University scholarship student. In 1943, at the age of 19, he dropped out of school, and joined the U.S. Navy, where he eventually became interested in pharmacology.[6] After serving in the Navy (a veteran of World War II), he returned to Berkeley, California, and in 1954 earned his Ph.D. in biochemistry from the University of California, Berkeley. Through the late 1950s, Shulgin completed post-doctoral work in the fields of psychiatry and pharmacology at University of California, San Francisco. After working at Bio-Rad Laboratories as a research director for a brief period, he began work at Dow Chemical Company as a senior research chemist.[6]

It was at this time that he had a series of psychedelic experiences that helped to shape his further goals and research, beginning with an experience with mescaline.[7]

I first explored mescaline in the late '50s, Three-hundred-fifty to 400 milligrams. I learned there was a great deal inside me.

— Alexander Shulgin, LA Times, 1995[7]

He would later write that everything he saw and thought "had been brought about by a fraction of a gram of a white solid, but that in no way whatsoever could it be argued that these memories had been contained within the white solid ... I understood that our entire universe is contained in the mind and the spirit. We may choose not to find access to it, we may even deny its existence, but it is indeed there inside us, and there are chemicals that can catalyze its availability."[6]

Shulgin's professional activities continued to lean in the direction of psychopharmacology, furthered by his personal experiences with psychedelics. But during this period he was unable to do much independent research. His opportunity for further research came with his development of Zectran, the first biodegradable pesticide, a highly profitable product. Dow Chemical Company, in return for Zectran's valuable patent, gave Shulgin great freedom. During this time, he created and patented drugs when Dow asked, and published findings on other drugs in journals such as Nature and the Journal of Organic Chemistry. Eventually, Dow Chemical requested that he no longer use their name on his publications.[6]

In 1965, Shulgin left Dow to pursue his own interests, and became a private consultant, also frequently teaching classes in the local universities and at the San Francisco General Hospital. Through his friend Bob Sager, head of the U.S. DEA's Western Laboratories, Shulgin formed a relationship with the DEA and began holding pharmacology seminars for the agents, supplying the DEA with samples of various compounds, and occasionally serving as an expert witness in court. He also authored a definitive law enforcement reference book[8] on controlled substances[6] and received several awards from the DEA.[6]

In recent years, Shulgin has worked on a series of N-allylated tryptamines including 5-MeO-DALT and 5-MeO-MALT.[9] On April 8, 2008, at the age of 82, he underwent surgery to replace a defective aortic valve.[10] On November 16, 2010, Dr. Shulgin suffered a stroke. He is expected to fully recover.[11] In December 2010, he suffered another stroke, followed by skin-grafting surgery to save his left foot from an amputation.

Independent research

In order to carry out consulting work with the DEA, Shulgin obtained a DEA Schedule I license for an analytical laboratory, which allowed him to possess and synthesize any otherwise illicit drug. Shulgin set up a chemical synthesis laboratory in a small building behind his house, which gave him a great deal of career autonomy. Shulgin used this freedom to synthesize and test the effects of psychoactive drugs.

In 1967, Shulgin was introduced to MDMA (ecstasy) by a graduate student in the medicinal chemistry group he advised at San Francisco State University. MDMA had been synthesized in 1912 by Merck and patented in 1912 as an intermediate of another synthesis in order to block competitors, but was never explored in its own right. Shulgin went on to develop a new synthesis method, and in 1976, introduced the chemical to Leo Zeff, a psychologist from Oakland, California. Zeff used the substance in his practice in small doses as an aid to talk therapy. Zeff introduced the substance to hundreds of psychologists around the nation, including Ann Shulgin, whom Alexander Shulgin met in 1979, and married in 1981.[6]

After judicious self-experiments, Shulgin enlisted a small group of friends with whom he regularly tested his creations, starting in 1960. They developed a systematic way of ranking the effects of the various drugs, known as the Shulgin Rating Scale, with a vocabulary to describe the visual, auditory and physical sensations. He personally tested hundreds of drugs, mainly analogues of various phenethylamines (family containing MDMA and mescaline), and tryptamines (family containing DMT and psilocybin). There are a seemingly infinite number of slight chemical variations, all of which produce variations in effect—some pleasant and some unpleasant, depending on the person, substance, and situation—all of which are meticulously recorded in Shulgin's lab notebooks. Shulgin published many of these objective and subjective reports in his books and papers.[6]

In 1994, two years after the publication of PiHKAL, the DEA raided his lab. The agency requested that Shulgin turn over his license for violating the license's terms, and he was fined $25,000 for possession of anonymous samples sent to him for quality testing. In the 15 years preceding the publication of PiHKAL, two announced and scheduled reviews failed to find any irregularities.[12] Richard Meyer, spokesman for DEA's San Francisco Field Division, has stated that, "It is our opinion that those books are pretty much cookbooks on how to make illegal drugs. Agents tell me that in clandestine labs that they have raided, they have found copies of those books."[6]

Bibliography

Books

Other notable publications

References

  1. ^ http://www.youtube.com/watch?v=FA8ddx_iC_g DIRTY PICTURES - Alexander Shulgin documentary movie trailer, SXSW 2010
  2. ^ Ancestry.com. California Birth Index, 1905-1995 [database on-line]. Provo, UT, USA: Ancestry.com Operations Inc, 2005. Original data: State of California. California Birth Index, 1905-1995. Sacramento, CA, USA: State of California Department of Health Services, Center for Health Statistics.
  3. ^ Ancestry.com. California Death Index, 1940-1997 [database on-line]. Provo, UT, USA: Ancestry.com Operations Inc, 2000. Original data: State of California. California Death Index, 1940–1997. Sacramento, CA, USA: State of California Department of Health Services, Center for Health Statistics.
  4. ^ Ancestry.com. California Death Index, 1940–1997 [database on-line]. Provo, UT, USA: Ancestry.com Operations Inc, 2000. Original data: State of California. California Death Index, 1940–1997. Sacramento, CA, USA: State of California Department of Health Services, Center for Health Statistics.
  5. ^ Ancestry.com. 1930 United States Federal Census [database on-line]. Provo, UT, USA: Ancestry.com Operations Inc, 2002. Year: 1930; Census Place: Berkeley, Alameda, California; Roll 111; Page: 1B; Enumeration District: 320; File: 1029.0.
  6. ^ a b c d e f g h i Bennett, Drake (2005-01-30). "Dr. Ecstasy". New York Times Magazine (New York Times). http://www.nytimes.com/2005/01/30/magazine/30ECSTASY.html. Retrieved 2006-07-08. 
  7. ^ a b Romero, Dennis (1995-09-05). "Sasha Shulgin, Psychedelic Chemist". Los Angeles Times. http://www.erowid.org/culture/characters/shulgin_alexander/shulgin_alexander_interview1.shtml. Retrieved 2006-07-08. 
  8. ^ Shulgin, Alexander (1988). Controlled Substances: Chemical & Legal Guide to Federal Drug Laws. Ronin Publishing. ISBN 0-914171-50-X. 
  9. ^ "Vice Magazine – The Last Interview With Alexander Shulgin". http://www.viceland.com/int/v17n5/htdocs/the-last-interview-with-alexander-shulgin-423.php. 
  10. ^ "MAPS News 6/19/2008". http://www.maps.org/sys/nq.pl?id=1610. 
  11. ^ "Psychedelic Research - Sasha Shulgin". http://psychedelicresearch.org/?p=125. 
  12. ^ "DEA Raid of Shulgin's Laboratory". Erowid. 2004-01-08. http://www.erowid.org/culture/characters/shulgin_alexander/shulgin_alexander_raid.shtml. Retrieved 2006-07-08. 

External links